How is brexanolone administered for treatment?

Brexanolone is administered intravenously. This method of delivery is significant due to the specific pharmacokinetics associated with brexanolone, which is a formulation of allopregnanolone, a neuroactive steroid. Intravenous administration allows for precise dosing and rapid onset of action, which is essential in treating conditions like postpartum depression. The intravenous route ensures that the medication directly enters the bloodstream, allowing it to quickly reach the central nervous system where it exerts its therapeutic effects. This method also helps in monitoring the patient closely during administration, given the need for continuous infusion over a 60-hour period.

The other routes listed—oral, topical, and inhalation—are not applicable for brexanolone. Oral administration might lead to variable absorption, while topical and inhalation methods are unsuitable for this specific medication due to its biochemical properties and requirement for controlled delivery.