Which medication is used as augmentation for partial response to SSRIs?

Bupropion is often used as an augmentation strategy for individuals who have only a partial response to selective serotonin reuptake inhibitors (SSRIs). It works through a different mechanism compared to SSRIs, primarily targeting the norepinephrine and dopamine neurotransmitters, which can enhance the overall antidepressant effects in patients who may not have fully responded to SSRIs alone.

In cases where SSRIs alone do not yield adequate symptom relief, introducing bupropion can provide a complementary effect, potentially leading to a more robust therapeutic response. Moreover, bupropion is sometimes favored because it has a lower risk of sexual side effects compared to SSRIs, making it a more desirable option for augmenting treatment.

While other medications listed may also have their own roles in treating depression or other mental health conditions, bupropion specifically is frequently indicated for this role in clinical practice when addressing partial responses to SSRIs.