Which of the following is a non-benzodiazepine anxiolytic?

Buspirone (Buspar) is classified as a non-benzodiazepine anxiolytic, which makes it distinct from the other medications listed. Buspirone functions by affecting neurotransmitters in the brain, particularly serotonin and dopamine, to reduce anxiety without the sedative effects typical of benzodiazepines. It is often used in the management of chronic anxiety disorders and can have a lower potential for dependence compared to benzodiazepines, making it a safer option for long-term treatment in many cases.

The other medications mentioned are all benzodiazepines, which are a different category of anxiolytics. Benzodiazepines, like Xanax, Ativan, and Klonopin, work by enhancing the effect of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, producing a calming effect. However, they are associated with risks such as sedation, dependency, and withdrawal symptoms, which are not concerns with buspirone when used appropriately. This distinction highlights why buspirone is the correct answer in this context.