Which of the following medications is associated with the treatment of depression and is not a benzodiazepine?

The correct answer is Trintellix, as it is an antidepressant medication specifically indicated for the treatment of major depressive disorder. Trintellix, which contains the active ingredient vortioxetine, belongs to the class of serotonin modulators and is known for its unique mechanism of action that involves not only inhibiting the reuptake of serotonin but also modulating various serotonin receptors. This makes it effective for alleviating symptoms of depression without the sedative effects commonly associated with benzodiazepines.

In contrast, Xanax is a benzodiazepine primarily used for the short-term management of anxiety and panic disorders, and it does not address the underlying mechanisms of depression. Elavil, known as amitriptyline, is a tricyclic antidepressant, but it can have sedative effects and is less commonly used as a first-line treatment today compared to newer antidepressants. Vistril, or hydroxyzine, is an antihistamine that can have anxiolytic properties but is not classified as an antidepressant and is often used for its sedative properties rather than for treating depression.

Therefore, Trintellix stands out as the appropriate choice for addressing depression explicitly without being classified as a benzodiazepine.