Which SSRI is known for having a shorter half-life and noticeable withdrawal effects if a dose is missed?

Paroxetine is known for its shorter half-life compared to other selective serotonin reuptake inhibitors (SSRIs). This characteristic means that the drug is eliminated from the body more quickly, which can lead to withdrawal symptoms if a dose is missed or if there is a sudden discontinuation. Patients may experience a variety of withdrawal effects, such as dizziness, irritability, and flu-like symptoms.

The pharmacokinetics of paroxetine contribute to this profile, making it crucial for healthcare providers to monitor patients closely when prescribing it, particularly when considering dose adjustments or discontinuation. Understanding the properties of paroxetine helps in managing treatment plans and addressing any potential side effects that may arise from missed doses.